Cobalt?containing spherical glass nanoparticles for therapeutic ion release

Bioactive glass nanoparticles (BGNPs) can be internalized by cells, allowing the intracellular release of dissolution products with therapeutic benefit. Different ions incorporated into network that promote angiogenesis via simulation hypoxia conditions and consequent activation pro-angiogenic genes. Here, novel monodispersed spherical dense BGNPs were obtained a modified Stober method SiO2–CaO–CoO composition, diameters 92 ± 1 nm, cobalt as ion. The presence Co2+ species role Co Ca modifiers in silica confirmed X-ray photoelectron spectroscopy 29Si solid-state magic-angle spinning nuclear magnetic resonance, respectively. Controlled ion was observed culture media, no cytotoxicity (4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide cell viability assay on human osteosarcoma cells direct contact nanoparticles. This study demonstrated BGNPs, these materials exhibit great potential delivery systems properties.